HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
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Protein Aliases: Homeodomain-only protein; Lung cancer-associated Y protein; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; Odd homeobox protein 1
Gene Aliases: CAMEO; HOD; HOP; HOPX; LAGY; NECC1; OB1; SMAP31; TOTO
UniProt ID: (Human) Q9BPY8
Entrez Gene ID: (Human) 84525