Immunogen sequence: MSAETASGPT EDQVEILEYN FNKVDKHPDS TTLCLIAAEA GLSEEETQKW FKQRLAKWRR SEGLPSECRS VTD; Positive Samples: mouse brain, mouse lung, rat lung; Cellular Location: Nucleus
HOPX is an atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. HOPX acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. HOPX prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. HOPX overexpression causes cardiac hypertrophy and may act as a tumor suppressor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GIIg15b; global ischemia induced protein GIIG15B; Global ischemia-induced gene 15B protein; global ischemia-induced protein 15B; homeobox only domain; Homeobox-only protein; homeodomain only protein; Homeodomain-only protein; Lung cancer-associated Y protein; mOB1; not expressed in choriocarcinoma clone 1; Not expressed in choriocarcinoma protein 1; odd homeobox 1; Odd homeobox protein 1
Gene Aliases: 1110018K11Rik; 1200015P04Rik; 2300002F06Rik; AI848177; AW490897; CAMEO; GIIg15b; Hdop; HOD; HOP; HOPX; LAGY; NECC1; OB1; Obl; SMAP31; TOTO