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Proteintech
HuD Polyclonal Antibody
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Product Details
24992-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HuD-specific Fusion Protein Ag21830 (1-40 aa encoded by BC036071)
Conjugate
Form
Liquid
Concentration
0.31 mg/mL
Amount
46.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MVMIISTME PQVSNGPTSN TSNGPSSNNR NCPSPMQTGA T (1-40 aa encoded by BC036071)
Target Information
HuD, otherwise known as ELAV-like protein 4 or PNEM, is a protein that in humans is encoded by the ELAVL4 gene. This human gene is located at 1p34 by in situ hybridization. The HuD/ELAVL4 protein is an RNA-binding protein. ELAVL4 has specificity for 3-prime uridylate-rich untranslated regions of growth factor mRNAs. HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the, half-life of the transcript is increased. Additionally, HuD is important in neurons during brain development and plasticity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; ELAV-like protein 4; Hu antigen D; HU-antigen D; HuD; paraneoplastic encephalomyelitis antigen; Paraneoplastic encephalomyelitis antigen HuD; RNA-binding protein HUD3; unnamed protein product
Gene Aliases: Elav; ELAVL4; HUD; PNEM; r-HuD; RGD1561943
UniProt ID: (Human) P26378, (Mouse) Q61701, (Rat) O09032
Entrez Gene ID: (Human) 1996, (Mouse) 15572, (Rat) 432358
RNA processing
mRNA processing
learning
locomotory behavior
RNA splicing
cerebral cortex neuron differentiation
dendrite morphogenesis
3'-UTR-mediated mRNA stabilization
positive regulation of 3'-UTR-mediated mRNA stabilization
neuron differentiation
regulation of mRNA stability
positive regulation of dendrite development
nervous system development
aging
associative learning
regeneration
response to endoplasmic reticulum stress
response to cocaine
cellular response to nerve growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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