This peptide corresponds to 14 amino acids near the carboxy terminus of human CCR3.
PEP-0303 can be used as a blocking peptide with polyclonal antibody PA5-19859.
CCR3 (C-C chemokine receptor type 3) binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1 delta. CCR3 trasnduces a signal by increasing the intracellular calcium ions level. It also serves as an alternative co-receptor with CD4 for HIV-1 infection. Other chemokines play important roles in inflammation and are critical for the recruitment of effector immune cells to sites of infection. Chemokines activate leukocytes by binding to G protein coupled receptors. The ever-growing chemokine receptor subtypes can be divided into 2 major groups, CXCR and CCR, based on the 2 major classes of chemokines.
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Protein Aliases: b-chemokine receptor; C-C chemokine receptor type 3; C-C CKR-3; CC chemokine receptor 3; CCR-3; CD193; chemokine (C-C motif) receptor 3; eosinophil CC chemokine receptor 3; Eosinophil eotaxin receptor; MGC102841
Gene Aliases: CC-CKR-3; CCR3; CD193; CKR3; CMKBR3
UniProt ID: (Human) P51677
Entrez Gene ID: (Human) 1232
Molecular Function: G-protein coupled receptor cell adhesion molecule cytokine receptor defense/immunity protein hydrolase immunoglobulin receptor superfamily immunoglobulin superfamily cell adhesion molecule phosphatase protein phosphatase receptor