This peptide corresponds to 15 amino acids near the center of human Hrk.
PEP-0369 can be used as a blocking peptide with polyclonal antibody PA5-20235.
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Hrk, a pro-apoptotic member of the Bcl-2 homology domain-3 (BH3)-only group of the Bcl-2 family of proteins, was also identified as novel protein induced during programmed neuronal death. It lacks significant homology to other Bcl-2 family members except for an 8-amino acid region that is similar to the BH3 motif of Bik. Hrk regulates apoptosis through interaction with the anti-apoptotic proteins Bcl-2 and Bcl-XL via this domain. It does not interact with the pro-apoptotic proteins Bax, Bak, or Bcl-XS. Hrk localizes to mitochondrial membranes in a pattern similar to that previously reported for Bcl-2 and Bcl-XL.
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Protein Aliases: Activator of apoptosis harakiri; activator of apoptosis Hrk; BCL2-interacting protein; BH3-interacting domain-containing protein 3; death protein 5; harakiri, BCL2 interacting protein (contains only BH3 domain); Neuronal death protein DP5
Gene Aliases: BID3; DP5; HARAKIRI; HRK
UniProt ID: (Human) O00198
Entrez Gene ID: (Human) 8739