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Invitrogen
Human MMP-14 (Prodomain-catalytic Domain) Recombinant Protein
Product Details
RP-77532
| Applications | Tested Dilution | Publications |
|---|---|---|
Control (Ctrl) |
Assay-dependent | - |
| Product Specifications | |
|---|---|
Species |
Human |
Expression System |
E. coli |
Amino acid sequence |
Human MMP-14 (prodomain-catalytic domain), amino acids Ser1-Gly265 with an Leu-Val-Thr-(His)6 His-tag sequence |
Tag |
His-tag |
Molecular weight |
30.860 kDa |
Class |
Recombinant |
Type |
Protein |
Conjugate |
Unconjugated |
Form |
Liquid |
Purification |
purified |
Storage buffer |
TBS, pH 7.5, with 5mM CaCl2 |
Contains |
no preservative |
Storage conditions |
-80° C, Avoid Freeze/Thaw Cycles |
Product Specific Information
RP-77532 is a purified recombinant MMP-14 (prodomain-catalytic domain) protein, expressed as a periplasmic protein in E. coli.
Target Information
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.4.24.80; matrix metallo protease; matrix metallopeptidase 14 (membrane-inserted); Matrix metalloproteinase-14; membrane type 1 metalloprotease; Membrane-type matrix metalloproteinase 1; Membrane-type-1 matrix metalloproteinase; MMP; MMP-14; MMP-X MT-MMP; MMP-X1; MMPs; MT-MMP 1; MT-MMP MT1-MMP; MT1-MMP
Gene Aliases: MMP-14; MMP-X1; MMP14; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS
UniProt ID: (Human) P50281
Entrez Gene ID: (Human) 4323
Molecular Function:
metalloprotease
angiogenesis
ovarian follicle development
response to hypoxia
endothelial cell proliferation
endochondral ossification
proteolysis
response to oxidative stress
male gonad development
response to mechanical stimulus
response to hormone
positive regulation of myotube differentiation
positive regulation of peptidase activity
response to organic cyclic compound
extracellular matrix disassembly
positive regulation of cell growth
lung development
positive regulation of cell migration
collagen catabolic process
zymogen activation
endodermal cell differentiation
chondrocyte proliferation
astrocyte cell migration
response to estrogen
positive regulation of B cell differentiation
negative regulation of Notch signaling pathway
embryonic cranial skeleton morphogenesis
branching morphogenesis of an epithelial tube
tissue remodeling
negative regulation of focal adhesion assembly
craniofacial suture morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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