This peptide corresponds to 15 amino acids near the carboxy terminus of human TEM5.
PEP-0558 can be used as a blocking peptide with polyclonal antibody PA5-20441.
Tumor endothelial markers (TEMs) are significantly up-regulated during angiogenesis and neoangiogensis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies. These include TEMs such as TEM1, TEM5, TEM7 and TEM8. TEM5 is a member of the adhesion family of G protein coupled receptors and is localized on the surface of endothelial cells. TEM5 is a seven-pass transmembrane receptor, unlike TEM1, TEM7 and TEM8 which span the membrane once. TEM5 is abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, and colon. Proteolytically processed soluble TEM5 mediates endothelial cell survival during angiogenesis by linking integrin to glycosaminoglycans.
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Protein Aliases: Adhesion G protein-coupled receptor A2; DKFZp434C211; DKFZp434J0911; FLJ14390; G protein-coupled receptor 124; G-protein coupled receptor 124; Tumor endothelial marker 5
Gene Aliases: ADGRA2; GPR124; KIAA1531; TEM5
UniProt ID: (Human) Q96PE1
Entrez Gene ID: (Human) 25960