A suggested positive control is rat thymus tissue lysate.
PA5-20823 can be used with blocking peptide PEP-0937.
IA-1, also known as INSM1, is an essential five zinc-finger transcription factor that while initially identified from an insulinoma cDNA library, is expressed in the developing nervous system. Specifically, IA-1 is expressed as early as E9.5 in mice in the fore-, mid- and hindbrain, spinal cord, retina, and olfactory bulb. It is thought that IA-1 functions as a transcriptional repressor, and is a part of several signaling pathways including those of Notch and sonic hedgehog in addition to that of Ngn3 during pancreatic endocrine cell differentiation. IA-1 is also expressed in multiple tumors, including the majority of neuroendocrine tumors tested so far as well as nearly 100% of all small cell lung carcinomas, indicating that IA-1 may be an important target in cancer therapy.
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Protein Aliases: insulinoma associated 1; insulinoma-associated 1; insulinoma-associated protein (IA-1); Insulinoma-associated protein 1; insulinoma-associated protein 1-like; Zinc finger protein IA-1
Gene Aliases: IA-1; IA1; INSM1