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Proteintech
IA-2/PTPRN Polyclonal Antibody
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Product Details
10584-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IA-2/PTPRN Fusion Protein Ag0923 (506-811 aa encoded by BC007713)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STPSWCEEP AQANMDISTG HMILAYMEDH LRNRDRLAKE WQALCAYQAE PNTCATAQGE GNIKKNRHPD FLPYDHARIK LKVESSPSRS DYINASPIIE HDPRMPAYIA TQGPLSHTIA DFWQMVWESG CTVIVMLTPL VEDGVKQCDR YWPDEGASLY HVYEVNLVSE HIWCEDFLVR SFYLKNVQTQ ETRTLTQFHF LSWPAEGTPA STRPLLDFRR KVNKCYRGRS CPIIVHCSDG AGRTGTYILI DMVLNRMAKG VKEIDIAATL EHVRDQRPGL VRSKDQFEFA LTAVAEEVNA ILKALPQ (506-811 aa encoded by BC007713 )
Target Information
IA-2 (insulinoma-associated protein 2, ICA512, PTPRN) is a member of the transmembrane protein tyrosine phosphatase (PTP) family located in secretory granules of neuroendocrine cells. The IA-2 protein is 979 amino acids in length and consists of a luminal domain, transmembrane domain, and cytoplasmic domain. Although a member of the PTP family, IA-2 lacks phosphatase activity with known substrates due to amino acid substitutions at critical sites in its PTP domain. Two paralog RPTPs, IA-2 and IA-2beta were identified as major autoantigens in type-1 diabetes mellitus. On granule exocytosis, the IA-2 cytoplasmic domain is cleaved and the resulting cytosolic fragment moves into the nucleus where it enhances the levels of phosphorylated STAT5 and STAT3, thereby inducing insulin gene transcription and granule biogenesis. IA-2 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 105 kDa islet cell antigen; BEM-3; Brain-enriched membrane-associated protein tyrosine phosphatase; IA-2var; ICA 512; ICA105; ICA512; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; Islet cell antigen 512; Islet cell autoantigen 3; protein tyrosine phosphatase, receptor-type, N; protein tyrosine phosphatase-like N; PTP IA-2; PTPLP; R-PTP-N; Receptor-type tyrosine-protein phosphatase-like N; unnamed protein product
Gene Aliases: IA-2; IA-2/PTP; IA2; ICA3; ICA512; mIA-A; mKIAA4064; PTPRN; R-PTP-N
UniProt ID: (Human) Q16849, (Rat) Q63259
Entrez Gene ID: (Human) 5798, (Rat) 116660, (Mouse) 19275
response to reactive oxygen species
luteinization
insulin secretion
insulin secretion involved in cellular response to glucose stimulus
positive regulation of transcription from RNA polymerase II promoter
regulation of secretion
positive regulation of type B pancreatic cell proliferation
dense core granule maturation
protein dephosphorylation
response to glucose
cytokine-mediated signaling pathway
second-messenger-mediated signaling
response to insulin
response to estrogen
response to cAMP
dephosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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