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Product Details
PA5-78012
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human IARS. The exact sequence is proprietary.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.45 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7, with 20% glycerol
Contains
0.025% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
RRID
AB_2735944
Product Specific Information
Positive Control: 293T, A431, HeLa, HepG2
Predicted Reactivity: Mouse (92%), Xenopus laevis (80%), Bovine (94%)
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
IARS is a member of aminoacyl-tRNA synthetases which catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5' UTRs.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ20736; IRS; isoleucine tRNA ligase 1, cytoplasmic; isoleucine tRNA synthetase; Isoleucine--tRNA ligase, cytoplasmic; isoleucine-tRNA synthetase; isoleucyl tRNA synthetase; Isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic
Gene Aliases: IARS; IARS1; Iarsl; ILERS; ILRS; IRS; PRO0785
UniProt ID: (Human) P41252
Entrez Gene ID: (Human) 3376, (Rat) 306804
Molecular Function:
aminoacyl-tRNA synthetase
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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