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| Applications | Tested Dilution | Publications |
|---|---|---|
Immunohistochemistry (IHC) |
1:20-1:50 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Recombinant protein corresponding to Human IBTK |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.05 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.2, with 40% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_2642609 |
Immunogen sequence: ILFVTQDGEG FRGRWFEEKR KSSEKKEILS NLHNSSSDVS YVSDINSVYE RIRLEKLTFA HRAVSVSTDP SGCNFAILQS DPKTSLYEIP AVSSSSFFEE FGKLLREADE MDSIHDVTFQ VGN
Highest antigen sequence identity to the following orthologs: Mouse - 88%, Rat - 89%.
The protein encoded by this gene binds to Bruton's tyrosine kinase (BTK) and downregulates BTK's kinase activity. In addition, the encoded protein disrupts BTK-mediated calcium mobilization and negatively regulates the activation of nuclear factor-kappa-B-driven transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Bruton agammaglobulinemia tyrosine kinase inhibitor; BTK-binding protein; IBtk; Inhibitor of Bruton tyrosine kinase; inhibitor of Bruton's tyrosine kinase-alpha; inhibitor of Bruton's tyrosine kinase-beta; inhibitor of Bruton's tyrosine kinase-gamma; RP1-93K22.1
Gene Aliases: BTBD26; BTKI; IBTK; KIAA1417
UniProt ID: (Human) Q9P2D0
Entrez Gene ID: (Human) 25998
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