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Invitrogen

ICAM-1 Polyclonal Antibody

1 Reference
View all (154) ICAM-1 (CD54) antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-96365

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1000-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50 - 1:200
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A recombinant fusion protein containing a sequence corresponding to amino acids 120-320 of human ICAM-1.
View immunogen

Conjugate

Unconjugated

Form

Liquid

Concentration

3.12 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

RRID

AB_2808167

Product Specific Information

Immunogen sequence: PLPSWQPVGK NLTLRCQVEG GAPRANLTVV LLRGEKELKR EPAVGEPAEV TTTVLVRRDH HGANFSCRTE LDLRPQGLEL FENTSAPYQL QTFVLPATPP QLVSPRVLEV DTQGTVVCSL DGLFPVSEAQ VHLALGDQRL NPTVTYGNDS FSAKASVSVT AEDEGTQRLT CAVILGNQSQ ETLQTVTIYS FPAPNVILTK P

Positive Samples: Raji, Mouse lung, Rat lung; Cellular Location: Membrane, Single-pass type I membrane protein

Target Information

ICAM-1 (CD54) is an 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. ICAM-1 has 7 potential N-linked glycosylation sites and shares considerable amino acid sequence homology with ICAM-3 (CD50) and ICAM-2 (CD102). ICAM-1 binds to integrins of type CD11a/CD18 (leukocyte adhesion molecule, LFA-1), or CD11b/CD18 (Mac-1) and is exploited by Rhinovirus as a receptor. ICAM-1 is expressed by activated endothelial cells and detected on epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase upon inflammation. ICAM-1 is also detected in some carcinoma and melanoma cells. Soluble ICAM-1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD54; cell surface glycoprotein P3.58; Human rhinovirus receptor; ICAM-1; Intercellular adhesion molecule 1; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor; Ly 47; Major group rhinovirus receptor; MALA-2; MALA2; MyD10; sCD54; soluble CD54; Surface antigen of activated B cells

Gene Aliases: BB2; CD54; ICAM; Icam-1; ICAM1; Ly-47; MALA-2; P3.58

UniProt ID: (Human) P05362, (Mouse) P13597, (Rat) Q00238

Entrez Gene ID: (Human) 3383, (Mouse) 15894, (Rat) 25464

Function(s)
ovarian follicle development regulation of leukocyte mediated cytotoxicity response to amphetamine T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell acute inflammatory response to antigenic stimulus T cell antigen processing and presentation positive regulation of cellular extravasation cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules leukocyte cell-cell adhesion cell aging sensory perception of sound regulation of cell shape response to ionizing radiation response to sulfur dioxide response to organic cyclic compound membrane to membrane docking regulation of cell adhesion extracellular matrix organization positive regulation of actin filament polymerization cellular response to nutrient levels cell adhesion mediated by integrin response to gonadotropin response to drug response to amino acid positive regulation of GTPase activity adhesion of symbiont to host positive regulation of nitric oxide biosynthetic process response to ethanol positive regulation of vasoconstriction response to copper ion viral entry into host cell receptor-mediated virion attachment to host cell positive regulation of peptidyl-tyrosine phosphorylation regulation of immune response leukocyte migration positive regulation of NF-kappaB transcription factor activity negative regulation of calcium ion transport interferon-gamma-mediated signaling pathway establishment of endothelial barrier positive regulation of ERK1 and ERK2 cascade cellular response to lipopolysaccharide cellular response to alkaloid cellular response to glucose stimulus cellular response to interleukin-1 cellular response to tumor necrosis factor cellular response to hypoxia establishment of Sertoli cell barrier regulation of ruffle assembly negative regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of endothelial cell apoptotic process single organismal cell-cell adhesion response to hypoxia response to lipopolysaccharide cellular response to organic substance
Process(es)
virus receptor activity receptor activity transmembrane signaling receptor activity integrin binding protein binding protein complex binding
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