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Invitrogen

ID1 Polyclonal Antibody

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Product Details

PA5-78014

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of mouse ID1. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.83 mg/mL

Amount

183 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol

Contains

0.025% ProClin 300

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2735946

Product Specific Information

Positive Control: A431, HeLa, HepG2, mouse ESC, ID1-transfected 293T

Predicted Reactivity: Rat (96%), Pig (90%), Rhesus Monkey (94%), Bovine (90%)

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

ID1 is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. It has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: bHLHb24; Class B basic helix-loop-helix protein 24; dJ857M17.1.2; dJ857M17.1.2 (inhibitor of DNA binding 1, dominant negative helix-loop-helix protein); DNA-binding protein inhibitor ID-1; Id1; Inhibitor of differentiation 1; Inhibitor of DNA binding 1; inhibitor of DNA binding 1, dominant negative helix-loop-helix protein; inhibitor of DNA binding 1, HLH protein; transcription regulator helix-loop-helix protein; unnamed protein product

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Gene Aliases: AI323524; BHLHB24; D2Wsu140e; ID; ID1; Idb1

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UniProt ID: (Human) P41134

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Entrez Gene ID: (Human) 3397, (Mouse) 15901

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Function(s)
transcription corepressor activity protein binding protein dimerization activity transcription regulator inhibitor activity transcription factor activity, sequence-specific DNA binding protein C-terminus binding transcription factor binding protein homodimerization activity protein N-terminus binding proteasome binding DNA-binding transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter angiogenesis endothelial cell morphogenesis apoptotic process transforming growth factor beta receptor signaling pathway heart development circadian rhythm negative regulation of transcription by transcription factor localization positive regulation of gene expression negative regulation of gene expression neuron differentiation BMP signaling pathway protein destabilization collagen metabolic process regulation of MAPK cascade negative regulation of sequence-specific DNA binding transcription factor activity blood vessel endothelial cell migration negative regulation of osteoblast differentiation regulation of angiogenesis negative regulation of transcription, DNA-templated response to antibiotic rhythmic process blood vessel morphogenesis lung morphogenesis lung vasculature development endothelial cell apoptotic process negative regulation of cold-induced thermogenesis negative regulation of endothelial cell apoptotic process transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development negative regulation of protein binding positive regulation of actin filament bundle assembly negative regulation of apoptotic process negative regulation of DNA binding negative regulation of endothelial cell differentiation positive regulation of epithelial cell proliferation negative regulation of dendrite morphogenesis regulation of vasculature development negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
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