Immunogen sequence: PLTALNTDPAG AVNKQGDSIL CR
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 100%.
ID4 is transcription factors containing a basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional transactivation by heterodimerization with bHLH proteins.
Protein Aliases: bHLHb27; Class B basic helix-loop-helix protein 27; DNA-binding protein inhibitor ID-4; Inhibitor of differentiation 4; Inhibitor of DNA binding 4; inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
Gene Aliases: BHLHB27; ID4; IDB4
UniProt ID: (Human) P47928
Entrez Gene ID: (Human) 3400
Molecular Function: DNA-binding transcription factor