Immunogen sequence: ANTDTRPGNLH GAFRGLRTDC SRSALNLSHS ELEEGGSFST RIRSHSTIRT LAFPQGNAFT IRTANGGYKF RWV
Highest antigen sequence identity to the following orthologs - mouse 81%, rat 78%.
Transcription regulator specifically required for multiciliate cell differentiation. Acts in a multiprotein complex containing E2F4 and E2F5 that binds and activates genes required for centriole biogenesis. Required for the deuterosome-mediated acentriolar pathway (PubMed:25048963). Plays a role in mitotic cell cycle progression by promoting cell cycle exit. Modulates GMNN activity by reducing its affinity for CDT1 (PubMed:21543332, PubMed:24064211).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IDAS; MCI; MCIDAS; McIdas protein; MCIN; multiciliate cell differentiation 1; Multiciliate differentiation and DNA synthesis-associated cell cycle protein; Multicilin; Protein Idas
Gene Aliases: IDAS; MCI; MCIDAS; MCIN
UniProt ID: (Human) D6RGH6
Entrez Gene ID: (Human) 345643