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Product Details
IFI6-101AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide take within amino acid region 80-130 on human Interferon alpha-inducible protein 6.
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Target Information
G1P3, also known as Interferon alpha-inducible protein 6 (IFI6) and Interferon-induced protein 6-16, is a 130 amino acid member of the IFI6 family of proteins. Localized to the mitochondria, G1P3 is a multi-pass membrane protein that is induced by IFN-α2β. G1P3 has been shown to play a major role in the apoptosis pathway. Specifically, G1P3 acts as a cell survival protein by inhibiting caspase-3 activity, which antagonizes apoptosis. G1P3 has been implicated in tumorigenesis and is the subject of therapeutic studies, as reducing G1P3-mediated antiapoptotic signals could suggest improved therapies for myeloma or other malignancies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ifi-6-16; Interferon alpha-inducible protein 6; interferon, alpha-inducible protein 6; interferon, alpha-inducible protein clone IFI-6-16; Interferon-induced protein 6-16
Gene Aliases: 6-16; FAM14C; G1P3; IFI-6-16; IFI6; IFI616
UniProt ID: (Human) P09912
Entrez Gene ID: (Human) 2537
release of cytochrome c from mitochondria
immune response
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of mitochondrial depolarization
type I interferon signaling pathway
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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