Melanoma differentiation associated gene 5, MDA5, is a pattern recognition receptor to transmit the signal.Once activated, both proteins signal through IPS-1 activating transcription factors NF- kappaB and IRF-3 and ultimately activating apoptosis, cytokine signaling, and inflammation. RIG-I is essential for signaling by influenza A, influenza B, human respiratory syncytial virus, paromyxoviruses, Japanese encephalitis virus. MDA5 is essential for signaling by picornavirus. Both RIG-I and MDA5 are responsible for signaling by West Nile virus.
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Protein Aliases: CADM-140 autoantigen; Clinically amyopathic dermatomyositis autoantigen 140 kDa; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide; Helicard; Helicase with 2 CARD domains; Hlcd; IDDM19; IFIH1; interferon induced, with helicase C domain 1; Interferon-induced helicase C domain-containing protein 1; Interferon-induced with helicase C domain protein 1; MDA 5; MDA-5; MDA5; melanoma differentiation associated protein-5; melanoma differentiation-associated gene 5; Melanoma differentiation-associated protein 5; Murabutide down-regulated protein; RH116; RIG-I-like receptor 2; RLR-2; RNA helicase-DEAD box protein 116
Gene Aliases: AGS7; Hlcd; IDDM19; IFIH1; MDA-5; MDA5; RH116; RLR-2; SGMRT1
UniProt ID: (Human) Q9BYX4
Entrez Gene ID: (Human) 64135