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Invitrogen
IFIT1 Polyclonal Antibody
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FIGURE: 1 / 1
IFIT1 Antibody (PA3-846) in WB
mBio 2018 -
FIG 5 Reduced temperature also affects IFN-alpha/beta induction. (A to C) MEFs were transfected with 50 µg poly(I:C) per million cells using electroporation. Pooled transfections were then divided among 30, 37, and 39degC temperature conditions. (A) Supernatants were assayed for biologically active IFN-alpha/beta as described in Materials and Methods. Data are presented as log 10 mean IU per milliliter +- S... View More
Product Details
PA3-846
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
aa 217-233 of mouse IFIT1
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
PA3-846 detects ISG56 (p56) from mouse samples.
PA3-846 has been successfully used in Western blot applications to detect a 39-58 kDa band.
Target Information
Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Exhibits antiviral activity against several viruses including human papilloma and hepatitis C viruses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Antiviral innate immune response effector IFIT1; GARG-16; Glucocorticoid-attenuated response gene 16 protein; IFI-56K; IFIT-1; Interferon-induced 56 kDa protein; Interferon-induced protein with tetratricopeptide repeats 1
Gene Aliases: Garg16; Ifi56; Ifit1; Ifit1b; ISG56; P56
UniProt ID: (Mouse) Q64282
Entrez Gene ID: (Mouse) 15957
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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