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Proteintech
IFITM2 Polyclonal Antibody
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Product Details
12769-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse,
Virus
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IFITM2 Fusion Protein Ag3451 (1-132 aa encoded by BC009696)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Amount
19.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2.
Immunogen sequence: MNHIVQTFS PVNSGQPPNY EMLKEEQEVA MLGAPHNPAP PTSTVIHIRS ETSVPDHVVW SLFNTLFMNT CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGIFMTIL LVIIPVLVVQ AQR (1-132 aa encoded by BC009696)
Target Information
IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 1-8D; Dispanin subfamily A member 2c; DSPA2c; Fragilis protein 3; fragilis R; IFITM2; ifm2; interferon induced transmembrane protein, like; Interferon-induced transmembrane protein 2; Interferon-inducible protein 1-8D; unnamed protein product
Gene Aliases: 1-8D; DSPA2c; fragilis3; IFITM2; Ifitm3l; mil-3
UniProt ID: (Human) Q01629, (Mouse) Q99J93
Entrez Gene ID: (Human) 10581, (Mouse) 80876
immune system process
response to biotic stimulus
response to virus
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
negative regulation of viral entry into host cell
defense response to virus
immune response
cellular response to interferon-beta
type I interferon signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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