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Abnova
IFITM3 Polyclonal Antibody, MaxPab™
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FIGURE: 1 / 4
IFITM3 Antibody (H00010410-D03P) in WB
Western Blot analysis of IFITM3 expression in transfected 293T cell line (H00010410-T01) by IFITM3 MaxPab polyclonal antibody.
Lane 1: IFITM3 transfected lysate(14.74 KDa).
Lane 2: Non-transfected lysate.
Lane 1: IFITM3 transfected lysate(14.74 KDa).
Lane 2: Non-transfected lysate.
Product Details
H00010410-D03P
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IFITM3 (AAH06794, 1 a.a. approximately 133 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
See Label
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: MNHTVQTFFS PVNSGQPPNY EMLKEEHEVA VLGAPHNPAP PTSTVIHIRS ETSVPDHVVW SLFNTLFMNP CCLGFIAFAY SVKSRDRKMV GDVTGAQAYA STAKCLNIWA LILGILMTIL LIVIPVLIFQ AYG
Target Information
IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 1-8U; Dispanin subfamily A member 2b; DSPA2b; Fragilis; Fragilis 3; Fragilis protein; ifitm-like protein 1; Interferon-induced transmembrane protein 3; Interferon-inducible protein 1-8U; Interferon-inducible protein 15; Mil-1; Mouse ifitm-like protein 1; unnamed protein product
Gene Aliases: 1-8U; 1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls; IFITM3; IP15; mil-1
UniProt ID: (Human) Q01628, (Mouse) Q9CQW9
Entrez Gene ID: (Human) 10410, (Mouse) 66141
immune system process
receptor-mediated endocytosis
negative regulation of cell proliferation
response to biotic stimulus
response to virus
negative regulation of viral transcription
response to interferon-gamma
response to interferon-alpha
response to interferon-beta
negative regulation of viral genome replication
innate immune response
negative regulation of viral entry into host cell
defense response to virus
type I interferon signaling pathway
immune response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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