IFITM3 (interferon induced transmembrane protein 3), also known as 1-8U or IP15, is a multi-pass membrane protein that belongs to the IFITM (interferon inducible transmembrane) family of proteins. IFITM proteins are induced by type I and type II interferons and contain multiple interferon (IFN)-stimulated response elements (ISREs) in their promoter regions. IFITM proteins play important roles in many cellular processes and their expression requires the presence of the chromatin remodeling SWI/SNF-like BAF complexes. Cellular processes involving IFITM proteins include cellular anti-proliferative activities and homotypic cell adhesion functions of interferons. In addition, IFITM genes are often upregulated in various cancer cells, suggesting a possible role in carcinogenesis. Localizing to the membrane, IFITM3 is a 133 amino acid protein that is induced by IFN-alpha and IFN-gamma. IFITM3 expression can be regulated by TEF-1, Brg-1 and Sp1.
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Protein Aliases: Dispanin subfamily A member 2b; DSPA2b; Fragilis; Fragilis 3; Fragilis protein; ifitm-like protein 1; Interferon-induced transmembrane protein 3; Interferon-inducible protein 1-8U; Interferon-inducible protein 15; Mil-1; Mouse ifitm-like protein 1
Gene Aliases: 1-8U; 1110004C05Rik; Cd225; Cdw217; DSPA2b; Fgls; IFITM3; IP15; mil-1