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Invitrogen
IFN alpha Polyclonal Antibody
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Product Details
321001
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant mouse interferon alpha
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
whole serum, PBS
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
RRID
Product Specific Information
Specificity: Neutralizes mouse interferon alpha.
Activity: Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells, where 5 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of mouse IFN alpha to an endpoint of 50%.
Store at -20°C for short-term use (less than 6 months). For long-term storage, aliquot and store at -70°C or below for retention of full activity. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% BSA.
Packaged by and distributed for PBL Assay Science.
Target Information
IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ifa; IFN alpha 1/13; IFN alpha 1b; IFN α; IFN-alpha-1; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; Interferon alpha 13 (IFNA13); interferon alpha 15; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha leukocyte (IFL); Interferon alpha-1; Interferon alpha-1/13 (IFN-alpha-1/13); interferon alpha-2; Interferon alpha-D (IFN alphaD); Interferon alpha1 (IFNA1); MGC138207; MGC138505; MGC138507; novel interferon alpha (Ifna) family member
Gene Aliases: Gm12597; Ifa1; Ifa2; Ifna1; Ifnaa; MuIFN-alpha-A; OTTMUSG00000007655
UniProt ID: (Mouse) P01572
Entrez Gene ID: (Mouse) 15962, (Mouse) 242517, (Mouse) 15965
adaptive immune response
T cell activation involved in immune response
natural killer cell activation involved in immune response
defense response
humoral immune response
cytokine-mediated signaling pathway
B cell differentiation
positive regulation of peptidyl-serine phosphorylation of STAT protein
B cell proliferation
defense response to bacterium
response to exogenous dsRNA
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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