IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.
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Protein Aliases: alpha-2a interferon; ifa; IFN α; IFN-alpha 1b; IFN-alpha-1; IFN-alpha-1/13; IFN-alpha-2; IFNAalphaIFN-alpha-1/13; IFNalpha; IFNα; interferon alpha 15; interferon alpha 1b; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family gene 1; interferon alpha family, gene 2; Interferon alpha-1; Interferon alpha-1/13; Interferon alpha-2; Interferon alpha-A; Interferon alpha-D; interferon, alpha 1; interferon, alpha 2; interferon-alpha1; LeIF A; LeIF D; MGC138207; MGC138505; MGC138507; novel interferon alpha (Ifna) family member
Gene Aliases: Gm12597; Ifa1; Ifa2; IFL; IFN; IFN-ALPHA; IFN-alpha1; IFN-alphaA; IFN-alphaD; IFNA; IFNA1; IFNA13; IFNA2; IFNA2A; IFNA2B; IFNA2C; IFNA@; Ifnaa; INFA2; MuIFN-alpha-A; OTTMUSG00000007655