Immunogen sequence: AKVDKRKQRS VFRDVLRAVE ERDFPTETIK FGPERMYIDC WVKKHTYDTF KEVLGSGMQY HLQSNEFLRN VFELGPPVML DAATLK
Highest antigen sequence identity to the following orthologs: Mouse - 97%, Rat - 95%.
Tis7, also known as IFRD1, is a 442 amino acid containing membrane associated, non-nuclear intracellular protein belonging to the IFRD family. A regulatory protein expressed in a variety of tissues, Tis7 is known to play an important role in the regulation of gene activity in the proliferative and/or differentiative pathways induced by NGF. Reports suggest that Tis7 may be an autocrine factor that attenuates or amplifies the initial ligand induced signal and might also augment the adaptive response by stimulating the production of differentiated enterocytes. Tis7 acts as a negative regulator of transcriptional activity and represses expression of genes involved in myogenesis, muscle maintenance, and regeneration in a histone deacetylase dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 12-O-tetradecanoylphorbol-13-acetate-induced sequence 7; Interferon-related developmental regulator 1; Nerve growth factor-inducible protein PC4; pheochromocytoma cell-4; TIS7; TPA induced sequence 7
Gene Aliases: IFRD1; PC4; TIS7
UniProt ID: (Human) O00458
Entrez Gene ID: (Human) 3475