FIGURE: 1 / 2
Immunogen sequence: ITKQADWARN IKEPKAAVEM YISAGEHVKA IEICGDHGWV DMLIDIARKL DKAEREPLLL CATYLKKLDS PGYAAETYLK MGDLK
Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This cytoplasmic protein contains seven WD repeats and an AF-2 domain which function by recruiting coregulatory molecules and in transcriptional activation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
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Protein Aliases: intraflagellar transport 122 homolog; Intraflagellar transport protein 122 homolog; WD repeat domain 10; WD repeat-containing protein 10; WD repeat-containing protein 140
Gene Aliases: CED; CED1; IFT122; SPG; WDR10; WDR10p; WDR140
UniProt ID: (Human) Q9HBG6
Entrez Gene ID: (Human) 55764