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          • Primary Antibodies ›
          • IGF-IB Antibodies

          Proteintech

          IGF1B Polyclonal Antibody, CoraLite® Plus 488

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          Cite IGF1B Polyclonal Antibody, CoraLite® Plus 488

          Additional Information:
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          • Antibody Testing Data (1)
          IGF1B Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          IGF1B Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          IGF1B Antibody (CL488-20215) in ICC/IF

          Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using CoraLite Plus 488 IGF1B-Specific antibody (CL488-20215) at dilution of 1:200. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          View Product

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          IGF1B Antibody in Immunocytochemistry (ICC/IF)

          Product Details

          CL488-20215

          Applications
          Tested Dilution
          Publications

          Immunocytochemistry (ICC/IF)

          1:50-1:500
          -
          Product Specifications

          Species Reactivity

          Human

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          Peptide

          Conjugate

          CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

          Excitation/Emission Max

          493/522 nm

          Form

          Liquid

          Concentration

          1000 µg/mL

          Amount

          100 µg

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol, 0.5% BSA

          Contains

          0.05% ProClin 300

          Storage conditions

          -20°C, store in dark

          Shipping conditions

          Wet ice

          Target Information

          Insulin-like growth factor-1 (IGF1), is structurally and functionally related to insulin but has a much higher growth-promoting activity. A variety of cellular responses are induced by IGF1, including cell proliferation, differentiation, migration, and survival. IGF1 stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regards to enhancing glucose uptake. In circulation, IGFs are predominantly bound to binding proteins (IGFBPs) which prolong the half-life of the IGFs and play a role in delivering them to target tissues. Low levels of IGF1 have been linked to Alzheimer's disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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          Cite this product

          Bioinformatics

          Protein Aliases: IGF-I; IGF1; Insulin-like growth factor 1; insulin-like growth factor 1 (somatomedin C); Insulin-like growth factor I; insulin-like growth factor I precursor; insulin-like growth factor IB; insulin-like growth factor IB prepropeptide; insulin-like growth factor precursor; Mechano growth factor; MGF; Somatomedin-C; unnamed protein product

          View more View less

          Gene Aliases: IBP1; IGF; IGF-1; IGF-I; IGF1; IGFI; MGF

          View more View less

          UniProt ID: (Human) P05019

          View more View less

          Entrez Gene ID: (Human) 3479

          View more View less

          Function(s)
          insulin receptor binding insulin-like growth factor receptor binding integrin binding hormone activity protein binding growth factor activity protein kinase activator activity transmembrane receptor protein tyrosine kinase activator activity receptor agonist activity
          Process(es)
          skeletal system development osteoblast differentiation cell activation epithelial to mesenchymal transition blood vessel remodeling signal transduction Ras protein signal transduction nervous system development muscle organ development circadian rhythm cell proliferation positive regulation of cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway response to heat glycolate metabolic process glial cell differentiation regulation of gene expression positive regulation of glycoprotein biosynthetic process positive regulation of cardiac muscle hypertrophy positive regulation of gene expression negative regulation of gene expression skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration muscle hypertrophy myotube differentiation myotube cell development positive regulation of smooth muscle cell migration cerebellar granule cell precursor proliferation positive regulation of cerebellar granule cell precursor proliferation proteoglycan biosynthetic process lung development positive regulation of cell migration androgen receptor signaling pathway mammary gland development exocrine pancreas development positive regulation of myelination activation of protein kinase B activity negative regulation of interleukin-1 beta production negative regulation of tumor necrosis factor production regulation of establishment or maintenance of cell polarity negative regulation of smooth muscle cell apoptotic process multicellular organism growth bone mineralization involved in bone maturation wound healing positive regulation of activated T cell proliferation negative regulation of apoptotic process positive regulation of DNA binding positive regulation of MAPK cascade protein kinase B signaling positive regulation of insulin-like growth factor receptor signaling pathway type B pancreatic cell proliferation regulation of nitric oxide biosynthetic process myoblast differentiation positive regulation of osteoblast differentiation positive regulation of glycogen biosynthetic process positive regulation of glycolytic process positive regulation of mitotic nuclear division positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of glucose import positive regulation of Ras protein signal transduction insulin-like growth factor receptor signaling pathway positive regulation of fibroblast proliferation lung alveolus development cell development positive regulation of smooth muscle cell proliferation branching morphogenesis of an epithelial tube inner ear development chondroitin sulfate proteoglycan biosynthetic process positive regulation of epithelial cell proliferation positive regulation of protein secretion protein stabilization regulation of protein metabolic process myoblast proliferation positive regulation of protein kinase B signaling negative regulation of oocyte development growth hormone receptor signaling pathway lung vasculature development lung lobe morphogenesis Type I pneumocyte differentiation Type II pneumocyte differentiation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis prostate gland growth prostate gland epithelium morphogenesis prostate gland stromal morphogenesis negative regulation of androgen receptor signaling pathway positive regulation of cell growth involved in cardiac muscle cell development negative regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of calcineurin-NFAT signaling cascade cellular response to glucose stimulus negative regulation of release of cytochrome c from mitochondria extrinsic apoptotic signaling pathway in absence of ligand receptor signaling pathway via STAT postsynaptic modulation of chemical synaptic transmission negative regulation of neuroinflammatory response negative regulation of beta-amyloid formation positive regulation of trophectodermal cell proliferation cellular response to beta-amyloid positive regulation of type B pancreatic cell proliferation positive regulation of vascular smooth muscle cell proliferation negative regulation of vascular associated smooth muscle cell apoptotic process cellular response to insulin-like growth factor stimulus positive regulation of myoblast proliferation positive regulation of transcription regulatory region DNA binding negative regulation of apoptotic signaling pathway negative regulation of extrinsic apoptotic signaling pathway
          It has to be done as per old AB suggested Products section.

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