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Product Details
PA5-120782
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 25-180 of human IGF2 (NP_0006031)
Conjugate
Form
Liquid
Concentration
7.16 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2914354
Product Specific Information
Positive test controls include: HepG2, SW480, Mouse brain. The target is usually found in the following locations: Secreted.
Immunogen sequence: AYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSERDV STPPTVLPDN FPRYPVGKFF QYDTWKQSTQ RLRRGLPALL RARRGHVLAK ELEAFREAKR HRPLIALPTQ DPAHGGAPPE MASNRK
Target Information
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ22066; FLJ44734; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; insulin-like growth factor II (IGF-II); Insulin-like growth factor II (somatomedin A); insulin-like growth factor II isoform 2 variant 4 preprotein; insulin-like growth factor type 2; MSA; Multiplication-stimulating activity; Multiplication-stimulating polypeptide; preptin; Somatomedin-A; T3M-11-derived growth factor
Gene Aliases: AL033362; C11orf43; GRDF; IGF-2; IGF-II; IGF2; IGFII; M6pr; Mpr; Peg2; PP1446; PP9974; RNIGF2
UniProt ID: (Human) P01344, (Rat) P01346, (Mouse) P09535
Entrez Gene ID: (Human) 3481, (Rat) 24483, (Mouse) 16002
skeletal system development
ossification
positive regulation of protein phosphorylation
platelet degranulation
glucose metabolic process
regulation of gene expression by genetic imprinting
regulation of transcription, DNA-templated
multicellular organism development
female pregnancy
memory
positive regulation of cell proliferation
insulin receptor signaling pathway
response to radiation
response to nutrient levels
response to estradiol
response to nicotine
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
wound healing
positive regulation of activated T cell proliferation
response to drug
positive regulation of catalytic activity
positive regulation of MAPK cascade
cellular protein metabolic process
response to ethanol
positive regulation of glycogen biosynthetic process
positive regulation of mitotic nuclear division
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of insulin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of cell division
positive regulation of protein kinase B signaling
cellular response to mechanical stimulus
positive regulation of protein serine/threonine kinase activity
positive regulation of receptor activity
positive regulation of glycogen (starch) synthase activity
osteoblast differentiation
cell proliferation
organ morphogenesis
response to organic cyclic compound
exocrine pancreas development
positive regulation of transcription from RNA polymerase II promoter
striated muscle cell differentiation
positive regulation of steroid hormone biosynthetic process
carbohydrate metabolic process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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