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Invitrogen
IGF2 Polyclonal Antibody
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FIGURE: 1 / 3
IGF2 Antibody (PA5-47946) in IHC (F)
Immunohistochemical analysis of IGF2 in immersion fixed frozen sections of mouse embryo (E13-17). Samples were incubated in IGF2 polyclonal antibody (Product # PA5-47946) using a dilution of 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown) and counterstained with hematoxylin (blue).
Product Details
PA5-47946
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant mouse IGF-II Ala25-Glu91
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 50% cross-reactivity with recombinant human IGF-II is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ22066; FLJ44734; H-IGF-2; IGF; IGF-II; Insulin like growth factor; Insulin-like growth factor 2; Insulin-like growth factor II; Multiplication-stimulating polypeptide
Gene Aliases: AL033362; Igf-2; Igf-II; Igf2; M6pr; Mpr; Peg2
UniProt ID: (Mouse) P09535
Entrez Gene ID: (Mouse) 16002
ossification
positive regulation of protein phosphorylation
carbohydrate metabolic process
glucose metabolic process
memory
organ morphogenesis
response to organic cyclic compound
exocrine pancreas development
response to nicotine
insulin receptor signaling pathway via phosphatidylinositol 3-kinase
positive regulation of activated T cell proliferation
response to drug
positive regulation of catalytic activity
positive regulation of MAPK cascade
positive regulation of glycogen biosynthetic process
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
negative regulation of natural killer cell mediated cytotoxicity
positive regulation of insulin receptor signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
striated muscle cell differentiation
positive regulation of cell division
positive regulation of protein kinase B signaling
positive regulation of protein serine/threonine kinase activity
positive regulation of steroid hormone biosynthetic process
positive regulation of receptor activity
positive regulation of glycogen (starch) synthase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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