Immunogen sequence: VVESCEQVNT DSETAVVNVT YSSKDQARQA LDKLNGFQLE NFTLKVAYIP DEMAAQQNPL QQPRGRRGLG QRGSSRQGSP GSVSKQKPCD LPLRLLVPTQ FVGAIIGKEG ATIRNITKQT Q
Highest antigen sequence identity to the following orthologs: Mouse - 95%, Rat - 94%.
Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: cancer/testis antigen 98; CT98; hKOC; IGF II mRNA binding protein 3; IGF-II mRNA-binding protein 3; IGF2 mRNA-binding protein 3; IMP-3; IMP3; insulin-l; insulin-like growth factor 2 mRNA binding protein 3; Insulin-like growth factor 2 mRNA-binding protein 3; insulin-like growth factor 2, binding protein 3; KH domain containing protein overexpressed in cancer; KH domain-containing protein overexpressed in cancer; KOC1; mIMP-3; VICKZ family member 3; VICKZ3
Gene Aliases: 2610101N11Rik; AA522010; Ab2-255; AL022933; AU045931; CT98; IGF2BP3; IMP-3; IMP3; KOC; KOC1; Koc13; mimp3; Neilsen; RGD1306512; VICKZ3