Insulin like growth factor binding protein 3 (IGFBP3) is a member of the superfamily of insulin like growth factor (IGF) binding proteins which include six high affinity IGF binding proteins (IGFBP) and at least four low affinity binding proteins referred to as IGFBP related proteins (IGFBPrP). The IGFBP members are cysteine rich proteins with conserved cysteine residues clustered in the amino terminal and the carboxy terminal regions of the molecule. The cDNA sequence encoding the mature human IGFBP3 is fused to the signal peptide of CD33. The 265 amino acid residue recombinant mature human IGFBP3 has a calculated molecular mass of approximately 29 kDa. Due to glycosylation, the recombinant protein migrates as 41 kDa in SDS-PAGE.
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Protein Aliases: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; growth hormone-dependent binding protein; IBP-3; IGF binding protein 3; IGF-binding protein 3; IGFBP; IGFBP-3; Insulin like growth factor binding protein; insulin-like growth factor binding protein 3; Insulin-like growth factor-binding protein 3; tcag7.703
Gene Aliases: AI649005; BP-53; IBP3; IGFBP-3; IGFBP3; IGgfbp3