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Proteintech
IGFBP3 Polyclonal Antibody
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Product Details
10189-2-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Chicken,
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
IGFBP3 Fusion Protein Ag0242 (134-291 aa encoded by BC000013)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: PGNASESEE DRSAGSVESP SVSSTHRVSD PKFHPLHSKI IIIKKGHAKD SQRYKVDYES QSTDTQNFSS ESKRETEYGP CRREMEDTLN HLKFLNVLSP RGVHIPNCDK KGFYKKKQCR PSKGRKRGFC WCVDKYGQPL PGYTTKGKED VHCYSMQSK (134-291 aa encoded by BC000013)
Target Information
IGFBP3 is a gene that belongs to the insulin-like growth factor binding protein (IGFBP) family. The gene encodes a protein that contains both an IGFBP domain and a thyroglobulin type-I domain. This protein is known to form a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. The complex circulates in the plasma and prolongs the half-life of IGFs while also altering their interaction with cell surface receptors. Various isoforms of the gene have been identified through alternate transcriptional splice variants. Diseases associated with IGFBP3 include Insulin-Like Growth Factor I and Acid-Labile Subunit Deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP53; Growth hormone dependent binding protein; growth hormone-dependent binding protein; IBP-3; IGF binding protein 3; IGF-binding protein 3; IGFBP; IGFBP-3; Insulin like growth factor binding protein; insulin-like growth factor binding protein 3; Insulin-like growth factor binding protein 3 precursor; Insulin-like growth factor-binding protein 3; tcag7.703
Gene Aliases: AI649005; BP-53; IBP3; IGFBP-3; IGFBP3; IGgfbp3
UniProt ID: (Human) P17936, (Mouse) P47878
Entrez Gene ID: (Human) 3486, (Mouse) 16009
regulation of cell growth
osteoblast differentiation
negative regulation of protein phosphorylation
protein phosphorylation
apoptotic process
negative regulation of cell proliferation
negative regulation of signal transduction
regulation of glucose metabolic process
negative regulation of smooth muscle cell migration
regulation of apoptotic process
positive regulation of apoptotic process
positive regulation of catalytic activity
positive regulation of MAPK cascade
regulation of insulin-like growth factor receptor signaling pathway
positive regulation of insulin-like growth factor receptor signaling pathway
cellular protein metabolic process
type B pancreatic cell proliferation
positive regulation of myoblast differentiation
negative regulation of smooth muscle cell proliferation
regulation of growth
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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