This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm.
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Protein Aliases: angiomodulin; IBP-7; IBP7; IGF-binding protein 7; IGFBP; IGFBP rP1; IGFBP-7; IGFBP-rP1; Insulin like growth factor binding protein; insulin-like growth factor binding protein 7; Insulin-like growth factor-binding protein 7; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; TAF; Tumor-derived adhesion factor
Gene Aliases: AGM; FSTL2; IBP-7; IGFBP-7; IGFBP-7v; IGFBP7; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF