Immunogen sequence: VTIKCTFSAT GCPSEQPTCL WFRYGAHQPE NLCLDGCKSE ADKFTVREAL KENQVSLTVN RVTSNDSAIY ICGIAFPSVP EARAKQTGGG TTLVVREIKL LSK
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 68%.
IGSF6 (DORA), a novel member of the immunoglobulin superfamily (IGSF) from human and rat expressed in dendritic and myeloid cells. Using a probe from the open reading frame of the rat cDNA, we isolated a cosmid which contains the entire mouse gene. By comparative analysis and reverse transcriptase polymerase chain reaction, we defined the intron/exon structure and the mRNA of the mouse gene and, with respect to human BAC clones, the human gene. The genes span 10 kb (mouse) and 12 kb (human), with six exons arranged in a manner similar to other members of the IGSF. All intron/exon boundaries follow the GT-AG rule. Expression of the mouse Igsf6 gene is restricted to cells of the immune system, particularly macrophages. Northern blot revealed a single mRNA of 2.5 kb, in contrast to the human gene which is expressed as two mRNAs of 1 and 2.5 kb. The human and mouse genes were localized to a locus associated with inflammatory bowel disease. Analysis of the flanking regions of the Igsf6 gene revealed the presence of an unrelated gene, transcribed from the opposite strand of the DNA and oriented such that the Igsf6 gene is encoded entirely within an intron. An identical organization is seen in human.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DORA; down-regulated by activation (immunoglobulin superfamily); IgSF6; Immunoglobulin superfamily member 6; immunoglobulin superfamily, member 6; Protein DORA
Gene Aliases: DORA; IGSF6
UniProt ID: (Human) O95976
Entrez Gene ID: (Human) 10261