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Bethyl Laboratories
Fen1 Polyclonal Antibody
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Product Details
IHC-00335
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 250 and 300 of human Flap Structure Endonuclease 1.
Conjugate
Form
Liquid
Concentration
0.50 mg/mL
Amount
50 µg
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Based on 100% sequence identity, this antibody is predicted to react with Sheep, Bovine, Horse, Pig, Panda, Orangutan, Gorilla, Chimpanzee, Northern white-cheeked gibbon and Little brown bat
Target Information
FEN-1 (Flap Endonuclease and Five prime Exonuclease) is a 42 a protein that functions as an endonuclease that cleaves branched DNA structures containing single-stranded 5' flaps or as an exonuclease on DNA nicks and gaps. FEN-1 endonuclease and exonuclease activities are stimulated by an association with proliferating cell nuclear antigen (PCNA) in the nucleus. FEN-1 is believed to have important roles in DNA replication and repair and is required in cell-free DNA replication systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNase IV; FEN-1; FEN1; Flap endonuclease 1; Flap structure-specific endonuclease 1; hFEN-1; Maturation factor 1; maturation factor-1; MF1; unnamed protein product
Gene Aliases: FEN-1; FEN1; MF1; RAD2
UniProt ID: (Human) P39748
Entrez Gene ID: (Human) 2237
magnesium ion binding
DNA binding
damaged DNA binding
double-stranded DNA binding
catalytic activity
nuclease activity
endonuclease activity
endodeoxyribonuclease activity
RNA-DNA hybrid ribonuclease activity
exonuclease activity
protein binding
double-stranded DNA exodeoxyribonuclease activity
5'-3' exonuclease activity
hydrolase activity
hydrolase activity, acting on ester bonds
5'-flap endonuclease activity
manganese ion binding
metal ion binding
flap endonuclease activity
double-strand break repair via homologous recombination
DNA replication
DNA repair
base-excision repair
base-excision repair, gap-filling
double-strand break repair
DNA recombination
cellular response to DNA damage stimulus
memory
UV protection
telomere maintenance via semi-conservative replication
DNA replication, removal of RNA primer
positive regulation of sister chromatid cohesion
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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