IKK gamma is the regulatory subunit of the inhibitor of the kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome.
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Protein Aliases: AMCBX1; FIP 3; FIP-3; FIP3; Fip3p; I kappa B kinase subunit gamma; I-kappa-B kinase gamma; I-kappa-B kinase subunit gamma; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK gamma; IKK-gamma; IKKAP1; IKKG; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP1; IP2; IPD2; mFIP-3; NEMO; NF kappa B essential modifier; NF kappa B essential modulator; NF-kappa B essential modulator; NF-kappa-B essential modifier; NF-kappa-B essential modulator
Gene Aliases: 1110037D23Rik; AI848108; AI851264; AMCBX1; AW124339; FIP-3; FIP3; Fip3p; IKBKG; IKK-gamma; IKK[g]; IKKAP1; IKKG; IMD33; IP; IP1; IP2; IPD2; NEMO; ZC2HC9