I kappa B kinase alpha (IKK alpha) is a component of a multiprotein kinase complex that regulates the activity of the transcription factor NF-kappa B. Activation of the IKK complex via upstream stimuli leads to phosphorylation and degradation of NF-kappaB bound I kappa B (Inhibitor of kappa B). Subsequently, free NF-kappaB dimers enter the nucleus and regulate the transcription of a variety of target genes involved in cell proliferation and differentiation, apoptosis, and inflammation, etc. The IKK complex consists of 2 highly homologous kinase subunits, IKK alpha and IKK beta, and a nonenzymatic regulatory component, IKK gamma/NEMO. The relative contributions of IKK alpha and IKK beta to the signaling complex vary according to the requirements of the cell. IKK beta plays a predominant role in immune responses, while IKK alpha alone appears to be sufficient for at least some developmental systems. Recently, IKK/NF-kappa B signaling pathway was studied as therapeutic targets in cancer.
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Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; IkappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IkBKA; IKK alpha; IKK-A; IKK-a kinase; IKK-alpha; IKK1; Inhibitor of nuclear factor kappa-B kinase subunit alpha; NFKBIKA; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NFkappaB inhibitor kinase alpha; TCF-16; Transcription factor 16
Gene Aliases: AI256658; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKK-alpha; IKK1; IKKA; NFKBIKA; TCF16
UniProt ID: (Human) O15111