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Bioss

IKK alpha/beta Polyclonal Antibody

View all (17) IKK alpha/beta antibodies

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Product Details

BS-10123R

Applications
Tested Dilution
Publications

Western Blot (WB)

Assay-dependent
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human IKK Alpha/IKK beta.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

IKK alpha/beta is encoded by CHUK (conserved helix-loop-helix ubiquitous kinase) and IKKB (inhibitor of kappa light polypeptide gene enhancer in B-cells) gene located in chromosome 10 and 8 respectively in humans. Upon stimulation by agents that activate the NF-kB pathway such as TNF alpha, the two subunits of IKK complex, IKK alpha and IKK -beta alongside a regulator NEMO (IKK gamma) phosphorylates IkB proteins. This targets the later for ubiquitin mediated degradation and phosphorylation of NF-kB leading to subsequent translocation to the nucleus. Phosphorylation at serine 176 and 180 located in the activation loop causes a confirmation change that is required for the activation of the kinases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Conserved helix-loop-helix ubiquitous kinase; EC 2.7.11.10; I kappa B kinase 1; I-kappa-B kinase 1; I-kappa-B kinase 2; I-kappa-B kinase alpha; I-kappa-B kinase-alpha; I-kappa-B-kinase beta; IkappaB kinase; IkappaB kinase alpha; IkB kinase alpha subunit; IKK alpha; IKK-1; IKK-2; IKK-A; IKK-a kinase; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa-B kinase subunit alpha; Inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKA; NFKBIKB; nuclear factor kappa B kinase subunit beta; Nuclear factor NF-kappa-B inhibitor kinase alpha; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor NFkappaB inhibitor kinase alpha; protein kinase; Serine/threonine protein kinase IKBKB; TCF-16; TCF17; Transcription factor 16; unnamed protein product

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Gene Aliases: AI132552; AI256658; AIM-1; BPS2; CHUK; Chuk1; Fbx24; Fbxo24; IKBKA; IKBKB; IKK-1; IKK-2; IKK-alpha; IKK-beta; IKK1; IKK2; IKK[b]; IKKA; IKKB; IKKbeta; IMD15; IMD15A; IMD15B; NFKBIKA; NFKBIKB; TCF16

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UniProt ID: (Human) O15111, (Human) O14920, (Mouse) O88351, (Rat) Q9QY78

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Entrez Gene ID: (Human) 1147, (Mouse) 12675, (Rat) 309361, (Human) 3551, (Mouse) 16150, (Rat) 84351

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding IkappaB kinase activity kinase activity transferase activity protein homodimerization activity macromolecular complex binding protein heterodimerization activity scaffold protein binding transferrin receptor binding receptor signaling protein serine/threonine kinase activity transferase activity, transferring phosphorus-containing groups protein kinase binding identical protein binding protein serine kinase activity non-receptor serine/threonine protein kinase protein modifying enzyme
Process(es)
pattern recognition receptor signaling pathway skeletal muscle contraction regulation of transcription from RNA polymerase II promoter inflammatory response immune response I-kappaB kinase/NF-kappaB signaling response to xenobiotic stimulus response to virus response to toxic substance anatomical structure morphogenesis response to acetate negative regulation of NF-kappaB transcription factor activity positive regulation of interferon-alpha production response to hydroperoxide tumor necrosis factor-mediated signaling pathway toll-like receptor 4 signaling pathway NIK/NF-kappaB signaling positive regulation of I-kappaB kinase/NF-kappaB signaling response to amino acid innate immune response positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity striated muscle cell differentiation response to cholecystokinin cellular response to tumor necrosis factor cellular response to virus morphogenesis of an epithelial sheet protein phosphorylation I-kappaB phosphorylation Rho protein signal transduction lactation response to organic substance phosphorylation signal transduction by protein phosphorylation osteoclast differentiation response to lipopolysaccharide mammary gland epithelial cell proliferation response to muscle stretch odontogenesis of dentin-containing tooth mammary gland alveolus development response to drug protein polyubiquitination stimulatory C-type lectin receptor signaling pathway antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent MyD88-dependent toll-like receptor signaling pathway positive regulation of macromolecule metabolic process regulation of tumor necrosis factor-mediated signaling pathway peptidyl-serine phosphorylation signal transduction involved in regulation of gene expression regulation of toll-like receptor signaling pathway toll-like receptor 3 signaling pathway TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway negative regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of transcription, DNA-templated T cell receptor signaling pathway stress-activated MAPK cascade protein maturation interleukin-1-mediated signaling pathway protein localization to plasma membrane negative regulation of cytokine production involved in inflammatory response regulation of establishment of endothelial barrier negative regulation of bicellular tight junction assembly B cell homeostasis positive regulation of cell proliferation positive regulation of sodium ion transport neuron projection development serine phosphorylation of STAT protein positive regulation of neuron death positive regulation of cation channel activity response to fatty acid
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