|Tested species reactivity||Pig|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant swine IL-1-beta.|
|Storage buffer||PBS, pH 7.2|
|Tested Applications||Dilution *|
|Western Blot (WB)||Assay Dependent|
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.