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IL-12B Polyclonal Antibody

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IL-12B Polyclonal Antibody

Product Details

17645-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

IL-12B Fusion Protein Ag11837 (29-328 aa encoded by BC067498)
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Amount

19.5 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DVYVVELDW YPDAPGEMVV LTCDTPEEDG ITWTLDQSSE VLGSGKTLTI QVKEFGDAGQ YTCHKGGEVL SHSLLLLHKK EDGIWSTDIL KDQKEPKNKT FLRCEAKNYS GRFTCWWLTT ISTDLTFSVK SSRGSSDPQG VTCGAATLSA ERVRGDNKEY EYSVECQEDS ACPAAEESLP IEVMVDAVHK LKYENYTSSF FIRDIIKPDP PKNLQLKPLK NSRQVEVSWE YPDTWSTPHS YFSLTFCVQV QGKSKREKKD RVFTDKTSAT VICRKNASIS VRAQDRYYSS SWSEWASVPC S (29-328 aa encoded by BC067498)

Target Information

IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kDa cytokine receptor like subunit encoded by this gene, and a 35 kDa subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CLMF p35; CLMF p40; Cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 subunit p35; IL-12 subunit p40; IL-12A; IL-12B; IL12; IL12 p40; IL12, subunit p40; IL12A; Interleukin; interleukin 12, p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40); interleukin-12 beta chain; Interleukin-12 subunit beta; natural killer cell stimulatory factor 2; cytotoxic lymphocyte maturation factor 2; IL12p40; natural killer cell stimulatory factor, 40 kD subunit; NK cell stimulatory factor chain 2; NKSF/CLMF; IL12p40; 40kD; NKSF1; NKSF2; RP23-388G23.1

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Gene Aliases: CLMF; CLMF2; IL-12B; IL12B; IMD28; IMD29; NKSF; NKSF2

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UniProt ID: (Human) P29460

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Entrez Gene ID: (Human) 3593

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Function(s)
cytokine receptor activity cytokine activity cytokine receptor binding interleukin-12 receptor binding protein binding growth factor activity interleukin-12 alpha subunit binding identical protein binding macromolecular complex binding interleukin-23 receptor binding protein heterodimerization activity
Process(es)
regulation of cytokine production positive regulation of leukocyte mediated cytotoxicity positive regulation of T cell mediated cytotoxicity positive regulation of defense response to virus by host natural killer cell activation involved in immune response positive regulation of lymphocyte mediated immunity positive regulation of T-helper 1 type immune response positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target negative regulation of inflammatory response to antigenic stimulus cell surface receptor signaling pathway JAK-STAT cascade cell proliferation response to UV-B cell migration natural killer cell activation negative regulation of interleukin-10 production negative regulation of interleukin-17 production positive regulation of granulocyte macrophage colony-stimulating factor production positive regulation of interferon-gamma production positive regulation of interleukin-10 production positive regulation of interleukin-12 production positive regulation of interleukin-17 production positive regulation of tumor necrosis factor production positive regulation of natural killer cell activation positive regulation of natural killer cell proliferation positive regulation of mononuclear cell proliferation positive regulation of tissue remodeling positive regulation of smooth muscle cell apoptotic process interleukin-12-mediated signaling pathway T-helper 1 type immune response T-helper cell differentiation T cell proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation T cell activation defense response to protozoan positive regulation of memory T cell differentiation T-helper 1 cell differentiation positive regulation of osteoclast differentiation positive regulation of cell adhesion oocyte development negative regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation negative regulation of protein secretion regulation of inflammatory response positive regulation of inflammatory response defense response to Gram-negative bacterium positive regulation of NK T cell activation positive regulation of NK T cell proliferation defense response to virus cellular response to lipopolysaccharide cellular response to interferon-gamma negative regulation of vascular endothelial growth factor signaling pathway positive regulation of NIK/NF-kappaB signaling negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of T-helper 17 type immune response positive regulation of T-helper 17 cell lineage commitment
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