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Immunogen sequence: AESCTSRPHI TVVEGEPFYL KHCSCSLAHE IETTTKSWYK SSGSQEHVEL NPRSSSRIAL HDCVLEFWPV ELNDTGSYFF QMKNYTQKWK LNVIRRNKHS CFTERQVTSK IVEVKKFFQI TCENSYYQTL VNSTSLYKNC KKLLLENNKN PTIKKNAEFE DQGYYSCVHF LHHNGKLFNI TKTFNITIVE DRSNIVPVLL GPKLNHVAVE LGKNVRLNCS ALLNEEDVIY WMFGEENGSD PNIHEEKEMR IMTPEGKWHA SKVLRIENIG ESNLNVLYNC TVASTGGTDT KSFILVRKAD MA; Positive Samples: NCI-H460; Cellular Location: Membrane, Single-pass type I membrane protein
IL18R1 is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. The gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q.
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Protein Aliases: CD218 antigen-like family member A; CD218a; CDw218a; cytokine receptor; IL-18R-1; IL-18R-alpha; IL-18R1; IL-1Rrp; IL1 receptor-related protein; IL18Ralpha2; IL1R-rp; interleukin 1 receptor related protein; Interleukin-18 receptor 1; Interleukin-18 receptor alpha
Gene Aliases: CD218a; CDw218a; IL-1Rrp; IL18R1; IL18RA; Il18ralpha; IL1RRP
UniProt ID: (Human) Q13478, (Mouse) Q61098
Entrez Gene ID: (Human) 8809, (Mouse) 16182, (Rat) 301365
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