P600 targets IL-2 in ELISA applications and shows reactivity with Human samples.
The P600 immunogen is recombinant human IL-2.
P600 detects IL-2 which has a predicted molecular weight of approximately 15 kDa.
The P600 IL2 polyclonal antibody has successfully been paired as the coating antibody in a sandwich ELISA with detection antibody M600B (biotinylated conjugate of clone BG5). Typical dilutions for sandwich ELISA include 1 µg/mL for coating and 0.125 - 0.25 µg/mL for detection.
Antibody P600 and biotinylated antibody M600B (clone BG5) have successfully been used in combination with recombinant IL2 protein SIL2 in ELISA applications.
Interleukin 2 (IL-2) is an immuno-modulatory cytokine that is important for the proliferation of activated T cells, differentiation of B cells, natural killer cells, monocytes and macrophages. IL-2 signals through the IL-2 receptor (IL-2R), a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL-4) and interleukin 7 (IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease that suggests an essential role of this gene in the immune response to antigenic stimuli.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Aldesleukin; IL-2; Interleukin-2; involved in regulation of T-cell clonal expansion; T cell growth factor; T-cell growth factor; TCGF
Gene Aliases: IL-2; IL2; lymphokine; TCGF
UniProt ID: (Human) P60568
Entrez Gene ID: (Human) 3558