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Invitrogen
IL-20 Polyclonal Antibody
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FIGURE: 1 / 2
IL-20 Antibody (PA5-47067) in Neu
Neutralization of IL-20 in BaF3 mouse pro-B cell line co-transfected with human IL-20 Rα and IL-20 Rβ. Samples were incubated in IL-20 polyclonal antibody (Product # PA5-47067). Recombinant Human IL-20 stimulates proliferation in the BaF3 mouse pro-B cell line co-transfected with human IL-20 Rα and IL-20 Rβ in a dose-dependent manner (orange line). Proliferation elicited by Recombinant Human IL-20 (2 ng/mL) is neutralized (green line) by increasing concentrations of Goat Anti-Human IL-20 Antigen Affinity-purified Polyclonal Antibody. The N... View More
Product Details
PA5-47067
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E. coli-derived recombinant human IL-20 Leu25-Glu176
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
In direct ELISAs, approximately 30% cross-reactivity with recombinant human (rh) IL-19 is observed, approximately 15% cross-reactivity with recombinant mouse IL-20 is observed, and less than 1% cross-reactivity with rhIL-10 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Cytokines that signal through Class II receptors form a distinct family that includes the interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has defined a cytokine subfamily that includes AK155, IL-19, IL-20, IL-22, and IL-24. IL-20 belongs to the IL-10 family and plays a role in skin inflammation and the development of hematopoietic cells. Little is known about its other biological functions and clinical implications. These cytokines display pro-inflammatory activities in different tissues, including skin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cytokine Zcyto10; four alpha helix cytokine; il 20; IL-20; IL-20s; ILN; Interleukin; Interleukin-20; MGC96907; PRO1801; UNQ852
Gene Aliases: IL-20; IL10D; IL20; UNQ852/PRO1801; ZCYTO10
UniProt ID: (Human) Q9NYY1
Entrez Gene ID: (Human) 50604
immune response
signal transduction
osteoclast differentiation
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of epidermal cell differentiation
positive regulation of keratinocyte differentiation
positive regulation of osteoclast differentiation
regulation of inflammatory response
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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