|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide of Human IL21 C terminal amino acids 118-146 [CDSYEKKPPKEFLERFKSLLQKMIHQHLS]|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.01M potassium phosphate with 0.14M NaCl|
|Contains||0.1% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-21354 detects IL-21 in Human samples.
PA1-21354 has been successfully used in ELISA and Immunocytochemistry procedures.
PA1-21354 immunogen corresponds to Synthetic peptide of Human IL21 C terminal amino acids 118-146 [CDSYEKKPPKEFLERFKSLLQKMIHQHLS].
A novel cytokine related to IL2 and IL15 was recently identified and designated IL21. The receptor for IL21 (IL21R, also termed NILR for novel Interleukin receptor) is a new member of the class I cytokine receptor family. IL21R forms a complex with the common cytokine receptor g chain, gc, and mediates IL21 signaling. Both IL21R and the gc are necessary for the IL21 function. IL21 and its receptor activate JAKSTAT signaling pathway. IL21R is expressed in spleen, thymus, natural killer (NK), T and B cell lines. IL21 plays a role in the proliferation and maturation of NK, B and T cell populations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.