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IL-31RA/CRL3 Polyclonal Antibody
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Product Details
BS-2631R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human IL-31RA, amino acids 401-500.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
IL-31 is a T cell cytokine that is preferentially produced by T helper type 2 cells. IL-31 signals through a heterodimeric receptor composed of the IL-31 receptor (IL-31R) and the oncostatin M receptor (OSM). This receptor complex recruits JAK1, JAK2, Stat1, Stat3 and Stat5 signaling pathways, as well as the PI3 kinase/AKT cascade. SHP-2 and Shc adapter molecules are also recruited and contribute to an increased activation of the MAP kinase pathway in response to IL-31. Overexpression of IL-31 in mice results in pruritus and skin dermatitis resembling human atopic dermatitis (AD). Comparisons between skin from patients with AD and healthy skin showed IL-31R expression at higher levels on epidermal keratinocytes in AD samples. Infiltrating cells, more numerous in skin from patients with AD compared with that of healthy individuals, expressed IL-31 mRNA. IL-31 may participate in the cause of itch sensation and promote scratching behavior in NC/Nga mice with atopic dermatitis, and may represent a novel target for antipruritic drug development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: class I cytokine receptor; CRL 3; CRL3Glmr; cytokine receptor NR10; Cytokine receptor-like 3; GLM R; GLM-R; GLM-RMGC125346; GP130 like receptor; Gp130-like monocyte receptor; Gp130-like receptor; HGLM R; hGLM-R; HGLMR; IL 31RA; IL-31 receptor subunit alpha; IL-31R subunit alpha; IL-31R-alpha; IL-31RA; IL-31RAGPLCRL; IL31R subunit alpha; interleukin 31RA; Interleukin-31 receptor subunit alpha; MGC125346; mGLM-R; Novel cytokine receptor 10; novel soluble type I cytokine receptor; NR10; PLCA 2; soluble type I cytokine receptor CRL3; type I cytokine receptor; unnamed protein product; ZcytoR17
Gene Aliases: CRL; CRL3; GLM-R; GLMR; GPL; hGLM-R; IL-31RA; IL31RA; NR10; PLCA2; PRO21384; UNQ6368/PRO21073/PRO21384; zcytoR17
UniProt ID: (Human) Q8NI17, (Mouse) Q8K5B1
Entrez Gene ID: (Human) 133396, (Rat) 688622, (Mouse) 218624
MAPK cascade
glandular epithelial cell differentiation
immune system process
acute inflammatory response to antigenic stimulus
defense response
transmembrane receptor protein tyrosine kinase signaling pathway
JAK-STAT cascade
positive regulation of cell proliferation
cytokine-mediated signaling pathway
cell differentiation
monocyte differentiation
macrophage differentiation
positive regulation of tyrosine phosphorylation of STAT protein
homeostatic process
negative regulation of macrophage activation
negative regulation of apoptotic process
positive regulation of transcription, DNA-templated
receptor signaling pathway via STAT
defense response to other organism
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of tyrosine phosphorylation of Stat5 protein
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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