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Invitrogen

IL-33 Polyclonal Antibody

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IL-33 Polyclonal Antibody

Product Details

PA5-23150

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5-2 µg/mL
-
Product Specifications

Species Reactivity

Dog, Human, Non-human primate

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A portion of amino acids 50-100 of human IL-33.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 0.2% gelatin

Contains

0.05% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2540677

Product Specific Information

Sequence homology: Chimpanzee (91%), Bovine (85%), Mouse (78%).

Target Information

IL-33 (Interleukin-33) is a 270 amino acid, highly divergent protein belonging to the IL-1 family with an IL-1-like C-terminal domain. IL-33 is a dual function protein that may function both as a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. IL-33 binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6. IL-33 activates NF-kappaB and MAP kinases, and drives production of TH2-associated cytokines from in vitro polarized TH2 cells. In vivo, IL-33 induces the expression of IL-4, IL-5, and IL-13 and leads to severe pathological changes in mucosal organs. IL-33 is proteolytically converted to a mature form by CASP1 and is highly expressed in high endothelial venules found in tonsils, Peyer's patches and mesenteric lymph nodes and is almost undetectable in placenta. Prolonged IL-33 treatment of mice led to the development of eosinophilia, splenomegaly, and severe pathological changes in mucosal organs such as lungs, esophagus and small intestine. Recent experiments have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine and an intracellular nuclear factor with transcriptional regulatory properties. Despite its predicted molecular weight, IL-33 will often run at higher molecular weight in SDS-PAGE. Studies have shown that IL-33 can also co-localize with heterochromatin and possesses transcriptional repressor activities, indicating that IL-33 may function as both a proinflammatory cytokine, and an intracellular nuclear factor with transcriptional regulatory properties.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: C9orf26; DVS27-related protein; growth stimulation-expressed; H-IL-33; homolog of mouse growth stimulation-expressed; IL-1F11; IL-33; ILN; Interleukin; interleukin 1 receptor-related protein; Interleukin-1 family member 11; Interleukin-1 receptor-like 1; Interleukin-33; Interleukin33; lacks exon 3 and the first 18bp of exon 5; lacks exons 3 and 4, and the first 18bp of exon 5; NF-HEV; nuclear factor for high endothelial venules; Nuclear factor from high endothelial venules; Protein DVS27; Protein ST2; RP11-575C20.2; soluble protein receptor; unnamed protein product

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Gene Aliases: C9orf26; DER4; DVS27; FIT-1; IL1F11; IL1RL1; IL33; IL33R; NF-HEV; NFEHEV; NFHEV; ST2; ST2L; ST2V; T1

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UniProt ID: (Human) Q01638, (Dog) O97863, (Human) O95760

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Entrez Gene ID: (Human) 9173, (Dog) 611442, (Dog) 403810, (Human) 90865

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Function(s)
interleukin-33 binding interleukin-33 receptor activity cytokine receptor activity interleukin-1 receptor activity protein binding hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating interleukin-33 receptor binding cytokine activity transmembrane signal receptor
Process(es)
negative regulation of T-helper 1 type immune response inflammatory response immune response signal transduction response to wounding macrophage differentiation negative regulation of interferon-gamma production positive regulation of chemokine production positive regulation of interleukin-5 production interleukin-33-mediated signaling pathway positive regulation of macrophage activation positive regulation of inflammatory response negative regulation of transcription from RNA polymerase II promoter positive regulation of chemokine secretion positive regulation of cytokine production macrophage activation involved in immune response microglial cell activation involved in immune response negative regulation of immunoglobulin production positive regulation of immunoglobulin production negative regulation of leukocyte migration positive regulation of type 2 immune response protein import into nucleus positive regulation of cellular defense response gene expression positive regulation of glycoprotein biosynthetic process positive regulation of gene expression positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of interleukin-13 production positive regulation of interleukin-4 production positive regulation of interleukin-6 production positive regulation of tumor necrosis factor production type 2 immune response protein kinase B signaling positive regulation of MHC class I biosynthetic process positive regulation of MHC class II biosynthetic process positive regulation of transcription from RNA polymerase II promoter positive regulation of multicellular organismal process defense response to virus positive regulation of protein kinase B signaling microglial cell proliferation inflammatory response to wounding extrinsic apoptotic signaling pathway negative regulation of inflammatory response to wounding negative regulation of macrophage proliferation antibacterial innate immune response positive regulation of neuroinflammatory response positive regulation of cytokine production involved in inflammatory response
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