IL-34 is secreted as a dimeric protein and currently belongs to no known cytokine family. It signals via the M-CSF Receptor, also known as CSF-1R and CD115, which is shared with M-CSF. IL-34 has no amino acid sequence homology to M-CSF, but they exhibit similarities in secondary structure and share overlapping functions. IL-34 has been shown to promote myeloid survival, proliferation, and differentiation, and to play a role in osteoclast formation. IL-34 expression has been detected in various tissues and is most abundant in the spleen.
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Protein Aliases: IL-34; ILN; Interleukin; Interleukin-34; Interleukin34
Gene Aliases: C16orf77; IL-34; IL34
UniProt ID: (Human) Q6ZMJ4
Entrez Gene ID: (Human) 146433
Molecular Function: interleukin superfamily