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|Tested species reactivity||Human, Mouse|
|Host / Isotype||Goat / IgG|
|Immunogen||Recombinant human IL5, expressed in Sf21 insect cells.|
|Storage Conditions||-20° C, Avoid Freeze/Thaw Cycles|
|Tested Applications||Dilution *|
|ELISA (ELISA)||1 µg/ml|
|Inhibition Assays (IA)||5.8 ug/ml|
|Neutralization (Neu)||5.8 µg/ml|
|Western Blot (WB)||2 mg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-24791 detects IL5 from human and mouse samples.
PA1-24791 has been successfully used in neutralization, inhibition assays, and Western blot procedures. Anti-Human IL5 was tested for its ability to neutralize the biological activity of recombinant, human IL5 on human TF-1 cells, adapted to grow with IL5 stimulation.
The PA1-24791 immunogen is recombinant human IL5, expressed in Sf21 insect cells.
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
B cell differentiation factor I; B-cell differentiation factor I; B-cell growth factor II; BCGF-II; colony-stimulating factor, eosinophil; cytotoxic T-lymphocyte inducer; EDF; eosinophil differentiation factor; interleukin-5; T-cell replacing factor; TRF
EDF; IL-5; IL5; TRF