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          • Primary Antibodies ›
          • IL-6 Antibodies

          Bioss

          IL-6 Polyclonal Antibody

          View all (192) IL-6 antibodies

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          Cite IL-6 Polyclonal Antibody

          Additional Information:
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          • Antibody Testing Data (1)
          IL-6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          IL-6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 1

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          IL-6 Antibody (BS-4587R) in IHC (P)

          Formalin-fixed and paraffin embedded human rectal carcinoma labeled with Anti-IL-6 Polyclonal Antibody, Unconjugated (bs-4587R) at 1:200 followed by conjugation to the secondary antibody and DAB staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          IL-6 Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          IL-6 Polyclonal Antibody

          Product Details

          BS-4587R

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:200
          -

          Immunohistochemistry (Frozen) (IHC (F))

          1:100-1:500
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1:500-1:1,000
          -
          Product Specifications

          Species Reactivity

          Bovine, Human, Mouse, Pig, Rabbit

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          KLH conjugated synthetic peptide derived from human IL-6, amino acids 51-150.
          3D Epitope / Immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Amount

          100 µg

          Purification

          Protein A

          Storage buffer

          0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

          Contains

          0.02% ProClin 300

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          Target Information

          IL-6 is a gene that encodes a cytokine that plays a role in inflammation and the maturation of B cells. The protein produced by this gene is an endogenous pyrogen that can induce fever in people with autoimmune diseases or infections. The gene is primarily expressed at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). Diseases associated with IL6 include Kaposi Sarcoma and Rheumatoid Arthritis, Systemic Juvenile.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: B-cell differentiation factor; B-cell hybridoma growth factor; B-cell stimulatory factor 2; BSF-2; CDF; CTL differentiation factor; cytokine; H-IL-6; Hybridoma growth factor; hybridoma growth factor peptide; IFN-beta-2; IL-6; IL6; ILN; interferon 6 precursor; Interferon beta-2; Interleukin; interleukin 6; interleukin 6 (interferon, beta 2); interleukin BSF-2; Interleukin HP-1; Interleukin-6; interleukin-6 protein; Interleukin6; M-IL-6; R-IL-6; unnamed protein product

          View more View less

          Gene Aliases: BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6; IL6

          View more View less

          UniProt ID: (Bovine) P26892, (Human) P05231, (Rabbit) Q9MZR1, (Pig) P26893, (Mouse) P08505

          View more View less

          Entrez Gene ID: (Bovine) 280826, (Human) 3569, (Rabbit) 100008733, (Pig) 399500, (Mouse) 16193

          View more View less

          Function(s)
          cytokine activity interleukin-6 receptor binding growth factor activity protein binding identical protein binding receptor binding
          Process(es)
          neutrophil apoptotic process hepatic immune response positive regulation of acute inflammatory response acute-phase response vascular endothelial growth factor production positive regulation of vascular endothelial growth factor production positive regulation of epithelial to mesenchymal transition response to activity neuron projection development positive regulation of chemokine production positive regulation of interleukin-6 production negative regulation of collagen biosynthetic process positive regulation of peptidyl-serine phosphorylation positive regulation of T cell proliferation positive regulation of tyrosine phosphorylation of STAT protein glucose homeostasis negative regulation of apoptotic process positive regulation of MAPK cascade positive regulation of osteoblast differentiation positive regulation of translation positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of insulin secretion positive regulation of B cell activation positive regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity response to glucocorticoid defense response to virus positive regulation of glial cell proliferation regulation of glucagon secretion interleukin-6-mediated signaling pathway cellular response to hydrogen peroxide cellular response to lipopolysaccharide T-helper 17 cell lineage commitment hepatocyte proliferation positive regulation of extracellular matrix disassembly liver regeneration positive regulation of apoptotic DNA fragmentation positive regulation of production of miRNAs involved in gene silencing by miRNA positive regulation of STAT cascade positive regulation of leukocyte adhesion to vascular endothelial cell germinal center B cell differentiation neutrophil mediated immunity monocyte chemotaxis positive regulation of immunoglobulin production positive regulation of leukocyte chemotaxis inflammatory response immune response humoral immune response JAK-STAT cascade positive regulation of cell proliferation negative regulation of cell proliferation regulation of vascular endothelial growth factor production positive regulation of gene expression negative regulation of lipid storage cytokine-mediated signaling pathway cell differentiation platelet activation endocrine pancreas development response to peptidoglycan negative regulation of chemokine production positive regulation of interleukin-1 beta production positive regulation of interleukin-10 production positive regulation of interleukin-17 production positive regulation of interleukin-21 production positive regulation of interleukin-8 production positive regulation of tumor necrosis factor production maintenance of blood-brain barrier positive regulation of apoptotic process negative regulation of fat cell differentiation regulation of angiogenesis negative regulation of bone resorption positive regulation of transcription, DNA-templated positive regulation of JAK-STAT cascade positive regulation of peptidyl-tyrosine phosphorylation negative regulation of neurogenesis defense response to Gram-negative bacterium defense response to Gram-positive bacterium regulation of protein transport positive regulation of lymphocyte activation T follicular helper cell differentiation regulation of astrocyte activation neuron cellular homeostasis glucagon secretion inflammatory response to wounding receptor signaling pathway via STAT cellular response to virus regulation of neuroinflammatory response positive regulation of neuroinflammatory response positive regulation of cytokine production involved in inflammatory response positive regulation of platelet aggregation positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of microglial cell activation positive regulation of T-helper 2 cell cytokine production negative regulation of primary miRNA processing negative regulation of interleukin-1-mediated signaling pathway positive regulation of type B pancreatic cell apoptotic process myeloid cell homeostasis negative regulation of protein kinase activity regulation of cell shape response to wounding cell growth positive regulation of protein import into nucleus, translocation T cell activation regulation of cell proliferation positive regulation of tyrosine phosphorylation of Stat3 protein defense response to protozoan regulation of apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of chemokine biosynthetic process regulation of circadian sleep/wake cycle, non-REM sleep positive regulation of nitric oxide biosynthetic process cell redox homeostasis positive regulation of T-helper 2 cell differentiation positive regulation of neuron differentiation negative regulation of gluconeogenesis positive regulation of DNA replication muscle cell cellular homeostasis negative regulation of hormone secretion negative regulation of muscle organ development positive regulation of epithelial cell proliferation negative regulation of cytokine secretion positive regulation of protein kinase B signaling positive regulation of transmission of nerve impulse branching involved in salivary gland morphogenesis epithelial cell proliferation involved in salivary gland morphogenesis positive regulation of ERK1 and ERK2 cascade cellular response to interleukin-1 cellular response to tumor necrosis factor negative regulation of neuron death positive regulation of estradiol secretion
          It has to be done as per old AB suggested Products section.

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