|Tested species reactivity||Mouse|
|Published species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant mouse IL-6|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PM626 targets IL-6 in ELISA, and WB applications and shows reactivity with mouse samples.
The PM626 immunogen is recombinant mouse IL-6.
PM626 detects IL-6 which has a predicted molecular weight of approximately 22 kDa.
This gene encodes a cytokine that functions in inflammation and the maturation of B cells. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Aldosterone-induced cardiomyocyte growth, and fibroblast migration and proliferation are mediated by TRAF3IP2.
PM626 was used in western blot to test if Aldo-mediated cardiomycocyte hypertrophy is dependent on TRAF3IP2.
|Somanna NK,Yariswamy M,Garagliano JM,Siebenlist U,Mummidi S,Valente AJ,Chandrasekar B||Cellular signalling (27:1928)||2015|
Adenosine A2A receptor deficiency exacerbates white matter lesions and cognitive deficits induced by chronic cerebral hypoperfusion in mice.
PM626 was used in western blot to study the effect of adenosine A2A receptor deficiency on chronic ischemic brain injury
|Duan W,Gui L,Zhou Z,Liu Y,Tian H,Chen JF,Zheng J||Journal of the neurological sciences (285:39)||2009|
Photodynamic therapy can induce a protective innate immune response against murine bacterial arthritis via neutrophil accumulation.
PM626 was used in blocking or activating experiment to study the protective effect of photodynamic therapy against bacterial arthritis and the mechanism involved
|Tanaka M,Mroz P,Dai T,Huang L,Morimoto Y,Kinoshita M,Yoshihara Y,Nemoto K,Shinomiya N,Seki S,Hamblin MR||PloS one (7:null)||2012|
Anti-IL-6 monoclonal antibodies protect against lethal Escherichia coli infection and lethal tumor necrosis factor-alpha challenge in mice.
PM626 was used in blocking/activating experiment to study the effect of interleukin 6 antibodies on Escherichia coli infection and tumor necrosis factor alpha challenge in mice
|Starnes HF,Pearce M,Yim J,Abrams J,Tewari A,Zou J||Journal of immunology (Baltimore, Md. : 1950) (148:null)||1992|
Rosuvastatin reduces microglia in the brain of wild type and ApoE knockout mice on a high cholesterol diet; implications for prevention of stroke and AD.
PM626 was used in immunohistochemistry to study the effect of rosuvastatin on microglia in mice
|Famer D,Wahlund LO,Crisby M||Biochemical and biophysical research communications (402:367)||2010|