|Tested species reactivity||Mouse|
|Published species reactivity||Mouse, Not Applicable|
|Host / Isotype||Rat / IgG1, kappa|
|Immunogen||Recombinant mouse IL-6.|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|ELISA (ELISA)||Assay Dependent|
|Flow Cytometry (Flow)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Neutralization (Neu)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
Interleukin 6 is a cytokine secreted by T cells and macrophages, has shown to exhibit activity in response to tissue damage and infection. They have also been found to be involved in various other activities like development of blood, cancer, embryonic development, and regulation of the immune system. IL6 is included in a family of other cytokines which include ciliary neurotrophic factor, cardiotrophin-1, leukemia inhibitory factor and interleukin 11. IL-6 can bring about differentiation through a receptor system which requires a specific receptor and a signaling subunit, gp130.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Mouse||Not Cited||Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization.||Jang JY,Lee JK,Jeon YK,Kim CW||BMC cancer (13:null)||2013|
|Not Applicable||Not Cited||
Liposome-delivered ATP effectively protects the retina against ischemia-reperfusion injury.
AMC0864 was used in immunohistochemistry to report the effect of ATP encapsulated in liposomes on the level of inflammation and neuronal death in the retina induced by ischemia reperfusion
|Dvoriantchikova G,Barakat DJ,Hernandez E,Shestopalov VI,Ivanov D||Molecular vision (16:2882)||2010|
||Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury.||Dvoriantchikova G,Barakat DJ,Hernandez E,Shestopalov VI,Ivanov D||Molecular vision (16:1907)||2010|
|Mouse||Not Cited||Toll-like receptor 4 contributes to retinal ischemia/reperfusion injury.||Dvoriantchikova G,Barakat DJ,Hernandez E,Shestopalov VI,Ivanov D||Molecular vision (16:1907)||2010|
Enhancement of antigen-presenting cell surface molecules involved in cognate interactions by immunostimulatory DNA sequences.
AMC0864 was used in blocking assay to demonstrate that immunostimulatory DNA up-regulates a distinct profile of cell surface molecules on macrophages and B cells in vitro and in vivo.
|Martin-Orozco E,Kobayashi H,Van Uden J,Nguyen MD,Kornbluth RS,Raz E||International immunology (11:1111)||1999|