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Invitrogen
IL-6 Receptor Monoclonal Antibody (B-R6)
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FIGURE: 1 / 2
IL-6 Receptor Antibody (MA1-80456) in ICC/IF
International journal of molecular sciences 2022 -
Figure 1 IL11 induces pancreatic stellate cell activation and invasion. ( a ) t-distributed stochastic neighbour embedding (tSNE) plots showing scRNA-seq expression of Il11ra1 , Il6ra and Il-6st ( gp130 ) in mouse pancreatic tissue. Cell clusters were identified using the Tabula Muris web tool ( https://tabula-muris.ds.czbiohub.org/ (accessed on 21 February 2022)). []. Black arrows indicate pancreatic stell... View More
Product Details
MA1-80456
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
C. elegans,
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
B-R6
Immunogen
CHO cells transfected with cDNA of the IL-6 receptor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
PBS
Contains
<0.1% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1x10^6 cells in 100 µL.
Mouse anti Human CD126 antibody, clone B-R6 recognizes human Interleukin-6 receptor subunit alpha, also known as CD126, IL-6R or Membrane glycoprotein 80.
Target Information
Interleukin 6 receptor (IL6R), also known as CD126 (Cluster of Differentiation 126), is a type I cytokine receptor. This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: CD126; CD126 antigen; gp80; IL-6 Receptor; il-6 receptor alpha; IL-6 receptor subunit alpha; IL-6R 1; ILN; Interleukin; Interleukin-6 receptor subunit alpha; Membrane glycoprotein 80; MGC104991
Gene Aliases: CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6R; IL6RA; IL6RQ
UniProt ID: (Human) P08887
Entrez Gene ID: (Human) 3570
hepatic immune response
monocyte chemotaxis
positive regulation of leukocyte chemotaxis
acute-phase response
positive regulation of cell proliferation
cytokine-mediated signaling pathway
endocrine pancreas development
positive regulation of chemokine production
positive regulation of interleukin-6 production
response to cytokine
positive regulation of tyrosine phosphorylation of Stat3 protein
positive regulation of osteoblast differentiation
positive regulation of smooth muscle cell proliferation
positive regulation of peptidyl-tyrosine phosphorylation
defense response to Gram-negative bacterium
interleukin-6-mediated signaling pathway
ciliary neurotrophic factor-mediated signaling pathway
extrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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